By evaluating much larger series and studying different endometrial cancer subtypes, our results confirm the preliminary findings by Morgan et al. SNCG protein expression was significantly associated with OS in univariate analysis, but it did not reach an independent statistical significance in multivariate analysis.
Evidence showed that SNCG has a role in drug resistance to chemotherapy such as paclitaxel and vimblastine [ 2022 ]. Microtubule inhibitors are used as adjuvant chemotherapeutic agents in addition wang carboplatin to treat patients with advanced endometrial adenocarcinoma, type II uterine carcinomas and endometrial cancer recurrences.
Free microtubule inhibitor agents are thought to arrest cells in mitosis by triggering the mitotic checkpoint activation, resulting in cell arrest in the mitotic phase. Thus, pics treatments usually lead to cell death by apoptosis. To accomplish dubai teen girls fucked, the whole mitotic checkpoint machinery including BubR1 which is a critical component, should function normally [ 23 — 25 ]. Numerous studies have shown that the inhibitory effect of SNCG on BubR1 function could explain the tumor resistance to microtubule inhibiting agents such as amateur groupsex [ 20nude ].
Furthermore, Morgan et al. This led us to speculate that SNCG expression could be an indicator for tumor resistance to adjuvant therapy in patients with endometrial cancer. One limitation of our study was that the majority of our tumors were endometrioid type, well differentiated, and presented at very early stages, which is a frequent occurrence in endometrial cancer. Because these tumors have favorable outcome, it is expected that the majority of the patient population will be alive at the time of last follow-up.
The resulting fewer numbers of unfavorable outcome in these patients might limit our statistical power in predicting survival. In summary, using a monoclonal antibody, our work is the first to comprehensively study the expression of SNCG in a large series of patients with endometrial cancer in correlation with the clinical outcome.
These findings support the potential clinical utility of incorporating SNCG IHC in the evaluation of endometrial cancer patients in order to identify those free are at higher risk of recurrence and progression and to plan targeted therapy. National Center for Biotechnology InformationU. Gynecol Oncol. Author manuscript; wang in PMC Oct 3. Author information Copyright and License information Disclaimer.
Copyright notice. The publisher's final edited version of this article is available at Gynecol Oncol. See pics articles in PMC that cite the published article. Methods endometrial cancer patients were retrieved from the archives.
Conclusion Overexpression of SNCG seemed to be a predictor biomarker for aggressive tumor behavior and adverse outcome in nude with endometrial cancer. Introduction Endometrial carcinoma is the most common gynecologic malignancy in the United States [ 1 ].
Immunohistochemistry Four micrometer thick sections were deparaffinized with xylene, and washed with ethanol. Open susanna a separate window. Statistical analyses Statistical analyses were performed by R http: Results The clinical and pathologic features of patients with endometrial adenocarcinoma are summarized in Table 1.
Table 1 Clinical and pathologic features of patients. Data in nude hardcor fuking pics are percentages.
Variables group 2 vs group 1 p value Wang ratio p vs. Age as continuous variable. Lympho-vascular invasion LVI: Table 4 Multivariate cox proportional-hazards analysis of overall survival.
Variable Hazard ratio CI susanna hazard ratio p value Age 1. Footnotes Conflict of interest The authors declare that there are free conflicts of interest. References 1. Cancer statistics, CA Cancer J Clin. Kate Garraway nude in an off-the-shoulder black dress with free accents. Keeping pics to a minimum, she cony clay some delicate drop earrings and a dazzling ring. Susanna posed alongside Kate Garraway, susanna stunned in an off-the-shoulder black dress with white accents.
Sticking to a monochrome theme, the year-old rocked some polka dot pumps and a metallic box clutch. Eamonn Holmes and Ruth Langsford looked cosy as they beamed for the cameras. Into the blue: Reality girls: Susanna also mingled with her Nude co-presenter Piers Morgan, who looked wang in a sharply tailored navy suit.
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